This article is providing non-experts with strategic considerations and general information about principles of peptide chemistry. The article is not encyclopedic but rather devoted to the history and bases of peptide synthesis.​

A «peptide synthesis» includes a large range of techniques and procedures that enable the preparation of materials ranging from small peptides to large proteins. The pioneering work of Bruce Merrifield, which introduced solid phase peptide synthesis (SPPS), dramatically changed the strategy of peptide synthesis and simplified the tedious and demanding steps of purification associated with solution phase synthesis.